![]() ![]() ![]() The funder provided support in the form of salaries for authors, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare no conflicts of interest related to the content of this article. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This article was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI13C1256). Received: JAccepted: SeptemPublished: October 10, 2016Ĭopyright: © 2016 Yoon et al. PLoS ONE 11(10):Įditor: Bing Xu, Brandeis University, UNITED STATES (2016) Cold Water Fish Gelatin Methacryloyl Hydrogel for Tissue Engineering Application. These data suggest that fish GelMA could be utilized in a variety of biomedical fields as a substitute for mammalian-derived materials.Ĭitation: Yoon HJ, Shin SR, Cha JM, Lee S-H, Kim J-H, Do JT, et al. Cells adhered, proliferated, and formed networks with surrounding cells on fish GelMA, and maintained high initial cell viability. The properties (mechanical strength, water swelling degree and degradation rate) of fish GelMA differed from those of porcine GelMA, and could be tuned to suit diverse applications. The lower melting point of fish gelatin compared to porcine gelatin allowed larger-scale synthesis of GelMA and enabled hydrogel fabrication at room temperature. In this study, we synthesized GelMA using fish-derived gelatin by a conventional GelMA synthesis method, and evaluated its physical properties and cell responses. Thus far, however, GelMA is mostly obtained from mammalian sources, which are associated with a risk of transmission of diseases, such as mad cow disease, as well as certain religious restrictions. Gelatin methacryloyl (GelMA) is a versatile biomaterial that has been used in various biomedical fields. ![]()
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